Chiral molecule detected

Like a pair of human hands, certain organic molecules have mirror-image versions of themselves, a chemical property known as chirality. These so-called “handed” molecules are essential for biology and have intriguingly been found in meteorites on Earth and comets in our Solar System. None, however, has been detected in the vast reaches of interstellar space, until now.

A team of scientists using highly sensitive radio telescopes has discovered the first complex organic chiral molecule in . The molecule, propylene oxide (CH3CHOCH2), was found near the center of our Galaxy in an enormous star-forming cloud of dust and gas known as Sagittarius B2 (Sgr B2).

The research was undertaken primarily with the National Science Foundation’s Green Bank Telescope (GBT) in West Virginia as part of the Prebiotic Interstellar Molecular Survey. Additional supporting observations were taken with the Parkes radio telescope in Australia.

“This is the first molecule detected in interstellar space that has the property of chirality, making it a pioneering leap forward in our understanding of how prebiotic are made in the Universe and the effects they may have on the origins of life,” said Brett McGuire, a chemist and Jansky Postdoctoral Fellow with the National Radio Astronomy Observatory (NRAO) in Charlottesville, Virginia.

“Propylene oxide is among the most complex and structurally intricate molecules detected so far in space,” said Brandon Carroll, a chemistry graduate student at the California Institute of Technology in Pasadena. “Detecting this molecule opens the door for further experiments determining how and where molecular handedness emerges and why one form may be slightly more abundant than the other.”

McGuire and Carroll share first authorship on a paper published today in the journal Science. They also are presenting their results at the American Astronomical Society meeting in San Diego, California.

Forming and Detecting Molecules in Space

Complex organic molecules form in interstellar clouds like Sgr B2 in several ways. The most basic pathway is through gas-phase chemistry, in which particles collide and merge to produce ever more complex molecules. Once organic compounds as large as methanol (CH3OH) are produced, however, this process becomes much less efficient.

To form more complex molecules, like propylene oxide, astronomers believe thin mantles of ice on dust grains help link into longer and larger structures. These molecules can then evaporate from the surface of the grains and further react in the gas of the surrounding cloud.

To date, more than 180 molecules have been detected in space. Each molecule, as it naturally tumbles and vibrates in the near vacuum of the interstellar medium, gives off a distinctive signature, a series of telltale spikes that appear in the radio spectrum. Larger and more have a correspondingly more complex signature, making them harder to detect.

Life's first handshake: Chiral molecule detected in interstellar space
The S (Latin for sinister, left) and R (Latin for rectus, right) versions of the chiral molecule propylene oxide, which was discovered in a massive star-forming region near the center of our Galaxy. This is the first detection of a chiral molecule in interstellar space. Credit: B. Saxton (NRAO/AUI/NSF)

To claim a definitive detection, scientists must observe multiple spectral lines associated with the same molecule. In the case of propylene oxide, the research team detected two such lines with the GBT. The third was at a frequency difficult to observe from the Northern Hemisphere due to satellite radio interference. Carroll, McGuire, and their colleagues used the Parkes telescope to tease out the final spectral line needed to verify their results.

The current data, however, do not distinguish between the left- and right-handed versions of the molecule. In additional to the same chemical composition, chiral molecules have the same melting, boiling, and freezing points, and the same spectra. “These spectra are like your hands’ shadows,” said Carroll. “It’s impossible to tell if a right hand or a left hand is casting the shadow.” This presents a challenge for researchers trying to determine if one version of propylene oxide is more abundant than the other.

More information: “Discovery of the interstellar chiral molecule propyleneoxide (CH3CHCH2O),” B. McGuire & P.B. Carroll et al., Science, June 2016. DOI: 10.1126/science.aae0328

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Source: Life’s first handshake: Chiral molecule detected in interstellar space


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